Dynamic QT response to cold‐water face immersion in long‐QT syndrome type 3
نویسندگان
چکیده
منابع مشابه
The congenital long QT syndrome Type 3: An update
Congenital long QT syndrome type 3 (LQT3) is the third in frequency compared to the 15 forms known currently of congenital long QT syndrome (LQTS). Cardiac events are less frequent in LQT3 when compared with LQT1 and LQT2, but more likely to be lethal; the likelihood of dying during a cardiac event is 20% in families with an LQT3 mutation and 4% with either an LQT1 or an LQT2 mutation. LQT3 is ...
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BACKGROUND Gain-of-function mutations in the voltage-gated sodium channel (Nav1.5) are associated with the long-QT-3 (LQT3) syndrome. Nav1.5 is densely expressed at the intercalated disk, and narrow intercellular separation can modulate cell-to-cell coupling via extracellular electric fields and depletion of local sodium ion nanodomains. Models predict that significantly decreasing intercellula...
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BACKGROUND Mexiletine (Mex) has been proposed as a gene-specific therapy for patients with long-QT syndrome type 3 (LQT3) caused by mutations in the cardiac sodium channel gene (SCN5A). The degree of QT shortening and the protection from arrhythmias vary among patients harboring different mutations. We tested whether the clinical response to Mex in LQT3 could be predicted by the biophysical pro...
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BACKGROUND Brugada syndrome and congenital long-QT syndrome (LQTS) type 3 (LQT3) are 2 inherited conditions of abnormal cardiac excitability characterized clinically by an increased risk of ventricular tachyarrhythmias. SCN5A gene that encodes the cardiac sodium channel α subunit is responsible for the 2 diseases, and more work is needed to improve correlations between SCN5A genotypes and assoc...
متن کاملEffect of Face to Face Nutrition Counseling on Metabolic Syndrome Parameters in Cigarette Quitters
Objective: Although smoking increase the risk of cardiovascular diseases, its quitting leads to weight gain due to increased appetite. The aim of this study was to determine the effect of face to face dietary counseling on metabolic syndrome (MetS) indices in cigarette quitter. Materials and Methods: This 9-week parallel randomized clinical trial was conducted by participation of 50 patients...
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ژورنال
عنوان ژورنال: Pediatrics International
سال: 2020
ISSN: 1328-8067,1442-200X
DOI: 10.1111/ped.14319